What effect is observed when a substance enters the body and then the bloodstream, affecting an organ?

When a substance enters the body and then the bloodstream, affecting an organ, systemic effects are observed. This occurs because the substance can travel throughout the circulatory system, impacting multiple organs and systems rather than just the site of entry. For example, if a toxic chemical is ingested or inhaled, it can be absorbed into the bloodstream and distributed to various organs such as the liver or kidneys, leading to widespread physiological changes or damage.

Systemic effects contrast with local effects, which are limited to the immediate area where the substance was introduced. Acute effects refer to severe responses that occur shortly after exposure, while chronic effects are long-term health issues that develop after repeated exposure over time. Thus, the distinction of systemic effects is specifically tied to the impact on the body as a whole rather than a localized response.